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M94A2897.TXT
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1994-10-25
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Document 2897
DOCN M94A2897
TI Pediatric AIDS in Sao Paulo-Brazil = 8 years later.
DT 9412
AU Queiroz W; Della Negra M; Yu CL; Paste AA; Soraggi Neto C; Silva LM;
Vazquez LM; Inst. Infectol. Emillio Ribas, Sao Paulo, SP, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):20 (abstract no. 053B). Unique
Identifier : AIDSLINE ICA10/94369678
AB OBJECTIVES: To show the clinical and epidemiological features of HIV
infected children followed in a specialized service in Sao Paulo,
Brazil. METHODS: Since 1986 419 children up to 13 years of age were
followed in our center, by the same medical team. We analyzed
retrospectively their risk factors, maternal risk factors (in case of
vertical transmission), follow up abandonment rate, death (age and causa
mortis) and present age distribution. Necropsy studies are performed
regularly. RESULTS: In our center 13.1% of the children are current
classified as P-o, 4.5% as P-1, 60.0% as P-2 and 22.4% are
seroreverters. The mean age of serorevertion was 9 months. Of all the
HIV infected children, 81.0% were infected by Vertical Transmission,
17.1% by blood or derivatives transfusion, 0.7% by high risk sexual
activity and the risk factor remains unknown in 1.2%. Among the HIV
vertically infected children the maternal risk factor was high risk
sexual activity in 17.5% of the cases, use of IV drugs in 16.4%,
association of sex and drugs in 17.8%, blood transfusion in 2.2% and
remains un-known in 46.1%. The follow up abandonment rate is 15% and 49%
of our patients have died. Among the vertically infected group the mean
age of death was 19.8 mo. and 52.5% of them died during the first year
of life. Septicemia and bacterial pneumonia were the most frequent causa
mortis. Curiously Pneumocystis carinii pneumonia (PCP) was infrequent as
a cause of death in our means. Currently 14.4% of the vertically
infected children in follow up are less than 2 years old, 60.8% are
between 2 and 5 years and 24.8% are older than 5. COMMENTS: Perinatal
transmission is the most important risk factor in our sample. The high
percentage of unknown maternal risk factor is due to the large number of
institutionalized children, abandoned soon after birth. The incidence of
death in the first year of life is high, but seldom due to PCP. The
vertically infected children who survive longer than 2 years show the
possibility of survival longer than 5 years. This may be due to the
different HIV versus host interactions, viral load and/or timing of
infection.
DE Acquired Immunodeficiency Syndrome/*MORTALITY/TRANSMISSION Adolescence
AIDS-Related Opportunistic Infections/MORTALITY Bacterial
Infections/COMPLICATIONS Cause of Death Child Child, Abandoned
Child, Preschool Human HIV Seropositivity Infant
Pneumonia/COMPLICATIONS Retrospective Studies Risk Factors
Septicemia/COMPLICATIONS MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).